Deciphering the role of autophagy in heart failure

Deciphering the role of autophagy in heart failure

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Heart failure (HF) refers to a progressive pathological condition when cardiac muscles fail to pump adequate blood supply (cardiac output) to meet the metabolic demand of the body.Among various cellular and Rangemaster Professional Plus 60 PROP60NGFSS/C 60cm Gas Cooker with Variable Gas molecular mechanisms identified for the onset and progression of HF, autophagy dysregulation is increasingly getting recognized.Autophagy is a natural cellular process that is observed in almost all eukaryotic cells.

Autophagy removes damaged/long-lived organelles, protein aggregates, and unwanted cellular compomemts via forming autophagosomes then fusing with lysosomes.Although mild-to-moderate induction of autophagy is deemed cytoprotective and adaptive, excessive or unchecked induction of autophagy can be detrimental and maladaptive.Both adaptive and Accessories - Gloves maladaptive autophagy play a vital role in the pathophysiology of HF.

In the current review, we provide an overview of autophagy regulation in HF and possible strategies targeting autophagy for the management of HF.